The Oldham Notebooks: an analysis of the development of IVF 1969–1978. II. The treatment cycles and their outcomes
نویسندگان
چکیده
This paper reports on the numbers of treatment cycles involved in the development of IVF (1969-1978) and their outcomes. We show that between 1969 and 1978: (i) a minimum of 282 women were involved in 495 cycles of potential laparoscopic oocyte retrieval (LOR); (ii) of these cycles, 457/495 proceeded to LOR to attempt egg collection; (iii) of which an outcome was recorded in 436/457; (iv) eggs were recovered in 388/436 of these; (v) inseminations were recorded in 331/388; (vi) embryos were recorded in at least 167; (vii) a total of 112 embryo transfers were attempted; and (viii) a maximum of 11 possible biochemical/preclinical pregnancies plus five clinical pregnancies were observed; (ix) from which two healthy live births resulted.
منابع مشابه
The Oldham Notebooks: an analysis of the development of IVF 1969–1978. I. Introduction, materials and methods
In this introductory paper, we describe the primary source material studied in this Symposium, namely a set of 21 notebooks and 571 pages of loose sheets and scraps of paper, which, on cross-referencing, have allowed us to reconstruct the sequence, timing and numbers of the laparoscopic cycles planned, attempted and undertaken between 9 January 1969 and 1 August 1978 by Robert Edwards, Patrick ...
متن کاملThe Oldham Notebooks: an analysis of the development of IVF 1969–1978. III. Variations in procedures
A survey is presented of the various technical and scientific challenges that had to be met during the 10-year period before the first successful live birth after IVF and embryo transfer was achieved, and the approaches used to meet these challenges is discussed. Records dated from January 1969 to July 1978 indicate that a minimum of 282 women were involved in 495 cycles scheduled for laparosco...
متن کاملThe Oldham Notebooks: an analysis of the development of IVF 1969–1978. V. The role of Jean Purdy reassessed
The role of Jean Purdy in the work leading to the birth of Louise Brown is assessed. We report that Purdy: (i) recorded and organized most of the data systematically; (ii) probably spent longer working in Oldham than did Edwards; (iii) whilst there, was primarily responsible for organizing laboratory supplies, including media preparation and testing; (iv) was involved in patient care; and (v) w...
متن کاملThe Oldham Notebooks: an analysis of the development of IVF 1969–1978. IV. Ethical aspects
Six evidential sources are examined to investigate how Edwards and Steptoe applied ethical standards to their research leading to the birth of Louise Brown: (i) Their own contemporary writings from 1970 onwards. (ii) Archival evidence from the British Medical Association (BMA), the British Association for the Advancement of Science (BAAS), and correspondence between Edwards and the Ford Foundat...
متن کاملThe Oldham Notebooks: an analysis of the development of IVF 1969-1978. VI. Sources of support and patterns of expenditure
Three major sources of financial support for the research undertaken by Edwards, Steptoe and Purdy between 1969 and 1978 are identified: the Ford Foundation, Oldham and District General Hospital (ODGH) Management Committee, and Miss Lillian Lincoln Howell via the American Friends of Cambridge University. Significant possible financial support from the World Health Organization was also identifi...
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